Potential Antimalarials. XIX. Syntheses and Testing of α-(Piperidin-2-yl)-α-(7′-trifluoromethylquinolin-4′-yl) methanol and α-(7-Bromo-1, 5-naphthyridin-4-yl)-α-( …

…, TMT Nguyen, B Kotecka, KH Rieckmann

Index: Barlin, Gordon B.; Nguyen, Trang M. T.; Kotecka, Barbara; Rieckmann, Karl H. Australian Journal of Chemistry, 1993 , vol. 46, # 1 p. 21 - 29

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Citation Number: 7

Abstract

Abstract The synthesis of the mefloquine analogue α-(piperidin-2-yl)-α-(7′- trifluoromethylquinolin-4′-yl) methanol (1) from 4-bromo-7-trifluoromethylquinoline and N- (hex-5-enyl) phthalimide through N-{4-[3′-(7 ″-trifluoromethylquinolin-4 ″-yl) oxiran-2′- yl] butyl} phthalimide 1′-oxide is reported. α-(7-Bromo-1, 5-naphthyridin-4-yl)-α-(piperidin- 2′-yl) methanol (2) was prepared by similar procedures.