Effects of [(N-alkyl-1, 3-dioxo-1H, 3H-isoindolin-5-yl) oxy] alkanoic acids,[(N-alkyl-1-oxo-1H, 3H-isoindolin-5-yl) oxy] butanoic acids, and related derivatives on chloride …

SD Wyrick, FT Smith, WE Kemp…

Index: Wyrick; Smith; Kemp; Grippo Journal of Medicinal Chemistry, 1987 , vol. 30, # 10 p. 1798 - 1806

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Citation Number: 16

Abstract

44 (N-alkyl-1, 3-dioxo-lH, 3H-isoindolin-5-yl) oxy] alkanoic acids and related derivatives have been synthesized and tested for ability to lower intracellular astrocytic chloride levels in an established in vitro cultured rat astrocyte model. In general, derivatives with nitrogen substituents such as relatively small alkyl groups are active at 0.1 mM and/or 0.5 mM levels whereas larger substituents such as cyclopentyl and cyclohexyl are less active. Halogen ...