Steroids

Alkylation of brain corticosteroid acetyltransferase by 17-hydroxyprogesterone 17-(9-oxo-10-chlorodecanoate) and related compounds

RH Purdy, PN Rao, JH Zoeller

Index: Purdy,R.H. et al. Steroids, 1973 , vol. 22, p. 139 - 150

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Citation Number: 1

Abstract

Abstract The addition of 17-hydroxyprogesterone 17-(9-oxo-10-chlorodecanoate)(1) at 1.5 μM to a partially purified preparation of corticosteroid acetyl-transferase from the primate brain at pH 7.4, results in a 50% inhibition of enzymatic activity after 30 minutes at 37. At this concentration the analogous 9-oxo-10-diazodecanoate, 8-carbomethyoxyoctanoate or 8- carboxyoctanoate esters show no effect on the activity of this enzyme. 9-Oxo-10- ...