Phenoxyl radicals can covalently attach to the C8 site of 2′-deoxyguanosine (dG) to generate oxygen-linked biaryl ether C8-dG adducts. To assess the structural impact of an O- linked C8-dG adduct in duplex DNA, C8-phenoxy-G (PhOG) and C8-4-fluorophenoxy-G (4FPhOG) were incorporated into the G3 position of the 12-mer Nar I recognition sequence (5′-CTCGGCXCCATC, where X= G, PhOG, or 4FPhOG) using solid-phase DNA ...
