The Journal of organic chemistry

Electrochemical Partial Fluorination of Organic Compounds. 74. Efficient Anodic Synthesis of 2-Fluoro-and 2, 3-Difluoro-2, 3-dihydrobenzofuran Derivatives1

KM Dawood, T Fuchigami

Index: Dawood, Kamal M.; Fuchigami, Toshio Journal of Organic Chemistry, 2004 , vol. 69, # 16 p. 5302 - 5306

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Citation Number: 15

Abstract

Anodic fluorination of 3-substituted benzofuran derivatives in a variety of fluoride salts resulted in the formation of three fluorinated products; two stereoisomers of 2, 3-difluoro-2, 3- dihydrobenzofuran (cis and trans) and cis-2-fluoro-3-hydroxy-2, 3-dihydrobenzofuran derivatives. Dehydrofluorination of the main products, cis-difluoro derivatives, furnished the nonaromatic 2-fluoro-3-benzofuranyledene derivatives instead of the aromatic 2- ...