Bulletin of the Chemical Society of Japan

The Synthesis of Cyclo-pentaglycyl-L-lysyl and Its Hydrolysis by Trypsin

M Ohno, N Izumiya

Index: Ohno; Izumiya Bulletin of the Chemical Society of Japan, 1965 , vol. 38, # 11 p. 1831 - 1840

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Citation Number: 10

Abstract

A cyclic hexapeptide, cyclo-pentaglycyl-L-lysyl hydrochloride (II L), has been synthesized in an attempt to obtain fundamental information about the syntheses of cyclic peptides; it has also been subjected to the action of trypsin. p-Methoxybenzyloxycarbonyltriglycyl-ε- benzyloxycarbonyl-L-lysylglycylglycine (XX) has been prepared by the saponification of the di-N-blocked hexapeptide ester which had been obtained by the condensation of p- ...