Bioorganic & medicinal chemistry letters

Structure–activity relationships of tulipalines, tuliposides, and related compounds as inhibitors of MurA

T Mendgen, T Scholz, CD Klein

Index: Mendgen, Thomas; Scholz, Therese; Klein, Christian D. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 19 p. 5757 - 5762

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Citation Number: 22

Abstract

The enzyme MurA performs an essential step in peptidoglycan biosynthesis and is therefore a target for the discovery of novel antibacterial compounds. We report here the inhibition of MurA by natural products from tulips (tulipalines and tuliposides), and the structure–activity relationships of various derivatives. The inhibition of MurA can be related to antibacterial activity, and MurA is probably one of the relevant molecular targets of the tulipaline ...