Discovery of 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1, 2, 4-triazole, FYX-051-a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia

…, K Matsumoto, T Iwanaga, H Nakamura, T Inoue…

Index: Sato, Takahiro; Ashizawa, Naoki; Matsumoto, Koji; Iwanaga, Takashi; Nakamura, Hiroshi; Inoue, Tsutomu; Nagata, Osamu Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 21 p. 6225 - 6229

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Citation Number: 32

Abstract

Our previous study identified 2-[2-(2-methoxy-ethoxy)-ethoxy]-5-[5-(2-methyl-4-pyridyl)-1H- [1, 2, 4] triazol-3-yl]-benzonitrile (2) as a safe and potent xanthine oxidoreductase (XOR) inhibitor for the treatment of hyperuricemia. Here, we synthesized a series of 3, 5-dipyridyl-1, 2, 4-triazole derivatives and, in particular, examined their in vivo activity in lowering the serum uric acid levels in rats. As a result, we identified 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)- ...