3-Substituted-(5-arylfuran-2-ylcarbonyl) guanidines as NHE-1 inhibitors

S Lee, T Kim, BH Lee, S Yoo, K Lee, KY Yi

Index: Lee, Sunkyung; Kim, Taemi; Lee, Byung Ho; Yoo, Sung-eun; Lee, Kyunghee; Yi, Kyu Yang Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1291 - 1295

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Citation Number: 17

Abstract

The C-3 substituents effect on NHE-1 inhibitory activity of (5-arylfuran-2-ylcarbonyl) guanidines, previously identified as potent NHE-1 inhibitors, was investigated. The introduction of amine or alkyl groups at the 3-position of the furan ring, next to the acylguanidine moiety, remarkably improves NHE-1 inhibitory potency. Especially the important finding is that 5-(2, 5-dichloro) phenyl and 5-(2-methoxy-5-chloro) phenyl ...