Novel tetracyclic imidazole derivatives: Synthesis, dynamic NMR study, and anti??inflammatory evaluation

R Rupčić, M Modrić, A Hutinec, A Čikoš…

Index: Rupcic, Renata; Modric, Marina; Hutinec, Antun; Cikos, Ana; Stanic, Barbara; Mesic, Milan; Pesic, Dijana; Mercep, Mladen Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 3 p. 640 - 656

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Citation Number: 6

Abstract

In our continuing efforts toward the development of disease modifying treatments for rheumatoid arthritis (RA), we are targeting inhibition of overproduction of tumor necrosis factor alpha cytokine (TNF-a) that is recognized as a key cytokine in RA progression. A small molecule inhibitor of TNF-a would be a novel potent anti-inflammatory drug having this distinguished mechanism of action. In the frame of our project aimed toward synthesis, ...