The identification of potent and selective imidazole-based inhibitors of B-Raf kinase

…, PJ Lovell, A Naylor, AD Reith, JG Steadman…

Index: Takle, Andrew K.; Brown, Murray J.B.; Davies, Susannah; Dean, David K.; Francis, Gerraint; Gaiba, Alessandra; Hird, Alex W.; King, Frank D.; Lovell, Peter J.; Naylor, Antoinette; Reith, Alastair D.; Steadman, Jon G.; Wilson, David M. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 2 p. 378 - 381

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Citation Number: 169

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A novel triarylimidazole derivative, SB-590885 (33), bearing a 2,3-dihydro-1H-inden-1-one oxime substituent has been identified as a potent and extremely selective inhibitor of B-Raf kinase. ... A novel triarylimidazole derivative, SB-590885 (33), bearing a 2,3-dihydro-1H-inden-1-one oxime substituent has ...