Synthesis and antidepressant activity of 5-phenyl-2-(2-propynylamino)-2-oxazolin-4-one and derivatives

CM Lee, BW Horrom, RJ Michaels…

Index: Lee,C.-M. et al. Journal of Medicinal Chemistry, 1972 , vol. 15, p. 1252 - 1255

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Citation Number: 3

Abstract

5-Phenyl-2-(2-propynylarnino)-2-oxazolin-4-one and derivatives were synthesized by heating 2-amino-5-phenyl-2-oxazolin-4-one and its derivatives with 2-propynylamine in ethanol. 2-[(l, l-Dialkyl-2-propynyl)-amino]-5-phenyl-2-oxazolin-4-ones were obtained by cyclization of 1-(a-chlorophenylacetyl)-3-(1, l-dialkyl-2-propyny1) ureas with sodium ethoxide in ethanol. These compounds were evaluated for antidepressant activity by the ...