e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Biocatalytic Cascade for the Synthesis of Enantiopure β??Azidoalcohols and β??Hydroxynitriles

JH Schrittwieser, I Lavandera, B Seisser…

Index: European Journal of Organic Chemistry, , # 14 p. 2293 - 2298

Full Text: HTML

Citation Number: 18

Abstract

... KGaA, Weinheim. Issue. European Journal of Organic Chemistry. ... The combined organic phases were washed with water (30 mL) and brine (30 mL), dried with Na 2 SO 4 and evaporated under reduced pressure to give the crude product. ... J. Mol. Catal. B 2006 , 39 , 9 –12 . ...

sodium cyanide Structure

1-chloro-3-phenoxypropan-2-one Structure

1-chloro-3-phen...

~89%

S-Methyl 4-chloro-3-hydroxybutyrate Structure

S-Methyl 4-chlo...

Methyl (3R)-4-cyano-3-hydroxybutanoate Structure

Methyl (3R)-4-c...

Pyrrole-1-propionic Acid Structure

Pyrrole-1-propi...

~65%

S-Methyl 4-chloro-3-hydroxybutyrate Structure

S-Methyl 4-chlo...

methyl (3S)-4-azido-3-hydroxybutanoate Structure

methyl (3S)-4-a...

sodium cyanide Structure

1-chloro-3-phenoxypropan-2-one Structure

1-chloro-3-phen...

~13%

S-Methyl 4-chloro-3-hydroxybutyrate Structure

S-Methyl 4-chlo...

Methyl (3R)-4-cyano-3-hydroxybutanoate Structure

Methyl (3R)-4-c...

sodium cyanide Structure

Pyrrole-1-propionic Acid Structure

Pyrrole-1-propi...

~34%

(R)-4-Chloro-3-hydroxybutyric acid methyl ester Structure

(R)-4-Chloro-3-...

(S)-methyl-(3-hydroxy-4-cyano)-butanoate Structure

(S)-methyl-(3-h...

sodium cyanide Structure

2-Chloroacetophenone Structure

2-Chloroacetophenone

~4%

3-Hydroxy-2-phenylpropionitrile Structure

3-Hydroxy-2-phe...

(S)-Styrene oxide Structure

(S)-Styrene oxide

Detail

2-Chloroacetophenone Structure

2-Chloroacetophenone

~4%

Styrene oxide Structure

N/A Structure

N/A Structure

Detail

sodium cyanide Structure

1-Chloro-2-octanone Structure

1-Chloro-2-octanone

~14%

(3R)-3-hydroxynonanenitrile Structure

(3R)-3-hydroxyn...

(R)-1-chloro-2-octanol Structure

(R)-1-chloro-2-...

Detail

2-Chloroacetophenone Structure

2-Chloroacetophenone

~4%

Styrene oxide Structure

N/A Structure

N/A Structure

Detail

An enzyme library approach to biocatalysis: development of n...

[Journal of the American Chemical Society, , vol. 124, # 31 p. 9024 - 9025]

An enzyme library approach to biocatalysis: development of n...

[Journal of the American Chemical Society, , vol. 124, # 31 p. 9024 - 9025]

A stereodivergent approach to substituted 4-hydroxypiperidin...

[Journal of Organic Chemistry, , vol. 67, # 22 p. 7869 - 7871]

A convenient preparation of optically pure 3-hydroxyglutaric...

[Tetrahedron Letters, , vol. 35, # 13 p. 1999 - 2002]

A convenient preparation of optically pure 3-hydroxyglutaric...

[Tetrahedron Letters, , vol. 35, # 13 p. 1999 - 2002]