Il Farmaco

Synthesis of 11-aryl-5H-imidazo [2, 1-c][1, 4] benzodiazepines and their benzodiazepine and A 1 adenosine binding activity

S Castellano, L Zorzin, C Florio, F Frausin…

Index: Castellano, Sabrina; Zorzin, Laura; Florio, Chiara; Frausin, Fabiana; Stefancich, Giorgio Farmaco, 2001 , vol. 56, # 10 p. 771 - 778

Full Text: HTML

Citation Number: 6

Abstract

In the context of a research program aimed at elucidating the properties of the 5H-imidazo [2, 1-c][1, 4] benzodiazepine system, a series of 11-aryl-5H-imidazo [2, 1-c][1, 4] benzodiazepines (3a–i) and their 10, 11-dihydro-derivatives (4a–i) has been synthesized. The synthetic strategy includes the preparation of the aryl-[1-(2-nitrobenzyl)-1H-imidazol-2- yl] methanones (5a–i) followed by their reduction and subsequent cyclization. Affinities of ...