Tetrahedron letters

An approach to the synthesis of dimeric resveratrol natural products via a palladium-catalyzed domino reaction

JL Jeffrey, R Sarpong

Index: Jeffrey, Jenna L.; Sarpong, Richmond Tetrahedron Letters, 2009 , vol. 50, # 17 p. 1969 - 1972

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Citation Number: 47

Abstract

A route for the rapid assembly of the carbon framework of several resveratrol natural products is presented. A palladium-catalyzed domino reaction of bromostilbene derivative 6 and tolane 7, involving two sequential Heck coupling reactions, provides access to the benzofulvene-based core of various resveratrol-derived natural products. The carbon skeleton of pallidol and its congeners is achieved by a Lewis acid-induced Nazarov-type ...