Molecules

Synthesis of acridine-based DNA bis-intercalating agents

GP Moloney, DP Kelly, P Mack

Index: Moloney, Gerard P.; Kelly, David P.; Mack Molecules, 2001 , vol. 6, # 3 p. 230 - 243

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Citation Number: 24

Abstract

Abstract: Methods for the synthesis of N 1, N 8-bis (9-acridinyl)-N 4-(4-hydroxybenzyl)- spermidine and N 1, N 7-(hydroxybenzyl)-bis-(3-aminopropyl) amine were investigated. Thus monocyanoethylation of 4-methoxybenzylamine followed by treatment with 4- chlorobutyronitrile gave the dinitrile N-(2-cyanoethyl)-N-(3-cyanopropyl)-4-methoxy- benzylamine. Subsequent in situ reduction with lithium aluminium hydride gave the ...