Monoaryl-and bisaryldihydroxytropolones as potent inhibitors of inositol monophosphatase

…, JB Ducep, B Lesur, F Piriou, P Raboisson…

Index: Piettre, Serge R.; Andre, Catherine; Chanal, Marie-Christine; Ducep, Jean-Bernard; Lesur, Brigitte; Piriou, Francois; Raboisson, Pierre; Rondeau, Jean-Michel; Schelcher, Charles; Zimmermann, Pascale; Ganzhorn, Axel J. Journal of Medicinal Chemistry, 1997 , vol. 40, # 26 p. 4208 - 4221

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Citation Number: 50

Abstract

The first successful preparation of mono-and disubstituted 3, 7-dihydroxytropolone involves a four-step synthetic scheme. Thus, bromination of 3, 7-dihydroxytropolone (8) followed by permethylation of the resultant products furnished gram quantities of intermediates 13-18. Single or double Suzuki coupling reactions between these permethylated monobromo-and dibromodihydroxytropolone derivatives and a variety of boronic acids delivered the ...