Abstract The influence of a number of factors, ie amine basicity, substrate structure, temperature and deuterium isotope effect, on the rate of phenyl β-bromoethyl sulphone and aryl β-chloroethyl sulphone 1, 2-elimination by reaction with amines in acetonitrile was investigated. On the basis of a comparative analysis of the ρ 0, β, k H/k D, ΔH‡ and ΔS math image values obtained with those for the reaction of β-halopropiophenone 1, 2-elimination ...