The synthesis and reactions of certain 3??substituted??2, 1??benzisothiazoles

AH Albert, DE O'Brien…

Index: Albert,A.H. et al. Journal of Heterocyclic Chemistry, 1978 , vol. 15, p. 529 - 536

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Citation Number: 12

Abstract

Abstract A new and general synthesis of 2, l-benzisothiazolin-3-ones (2) is described from the corresponding isatoic anhydride (3) and potassium hydrogen sulfide which gives the thioanthranilic acid (4) which is readily oxadized and ring closed to 2 with hydrogen peroxide. Phosphorus oxy-chloride converted 3-hydroxy-2, 1-benzisothiazole to 3-chloro-2, 1-benzisothiazole which gave a number of different 3-substiluted 2, 1-benzisothiazolesby ...