Selective cross-coupling of organic halides with allylic acetates

LL Anka-Lufford, MR Prinsell…

Index: Anka-Lufford, Lukiana L.; Prinsell, Michael R.; Weix, Daniel J. Journal of Organic Chemistry, 2012 , vol. 77, # 22 p. 9989 - 10000

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Citation Number: 39

Abstract

A general protocol for the coupling of haloarenes with a variety of allylic acetates is presented. Strengths of the method are a tolerance for electrophilic (ketone, aldehyde) and acidic (sulfonamide, trifluoroacetamide) substrates and the ability to couple with a variety of substituted allylic acetates. Secondary alkyl bromides can also be allylated under slightly modified conditions, demonstrating the generality of the approach. Finally, the coupling of ...