Synthesis of carboxymethyl GLA-60 ether derivatives containing an olefin in their chains and their LPS-antagonistic activities

…, Y Watanabe, M Shiozaki, S Kanai, S Kurakata

Index: Nakamura, Tsuyoshi; Watanabe, Yukiko; Shiozaki, Masao; Kanai, Saori; Kurakata, Shin-ichi Bulletin of the Chemical Society of Japan, 2003 , vol. 76, # 5 p. 1011 - 1022

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Abstract

Anomeric carboxymethyl GLA-60 olefine derivatives having ether chains instead of ester chains in their side chains were synthesized and their biological activities toward both human U937 cells and mouse PEC-macrophage cells were measured. The species-specific behavior of these compounds in humans (LPS-antagonistic) and mice (very weak LPS- antagonistic, but almost inactive) found this time was different from that in humans (LPS- ...