… metabolites of cyclophosphamide. A comprehensive kinetic analysis of the interconversion of cis-and trans-4-hydroxycyclophosphamide with aldophosphamide and …

G Zon, SM Ludeman, JA Brandt, VL Boyd…

Index: Zon, Gerald; Ludeman, Susan Marie; Brandt, Joan A.; Boyd, Victoria L.; Oezkan, Gunay; et al. Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 466 - 485

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Citation Number: 66

Abstract

Multinuclear (31P, 13C, 2H, and 'H) Fourier-transform NMR spectroscopy, with and without isotopically enriched materials, was used to identify and quantify, as a function of time, the following intermediary (short-lived) metabolites of the anticancer prodrug cyclophosphamide (1, Scheme I): cis-4-hydroxycyclophosphamide (cis-a), its trans isomer (trans-2), aldophosphamide (3), and its aldehyde-hydrate (5). Under a standard set of reaction ...