Pyridazinones. 2. Synthesis and antisecretory and antiulcer activities of thiourea and 2-cyanoguanidine derivatives

…, H Shimamura, Y Tsukamoto, K Yoshihara…

Index: Yamada, Toshihiro; Nobuhara, Youichi; Shimamura, Hiroshi; Tsukamoto, Yoshitsugu; Yoshihara, Kazuo; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 373 - 381

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Citation Number: 20

Abstract

In an effort to develop new types of antiulcer agents, we synthesized a series of novel 2-[w- (thioureido) alkyl]-and 2-[w-(cyanoguanidino) alkyl]-3 (2H)-pyridazinone derivatives. All target compounds were evaluated for gastric antisecretory activity in the pylorus-lygated rat by the method of Shay, and selected compounds were evaluated in the stress-induced ulcer test in rats. Structure-activity relationships were established. Two series of the compounds ...