The Asymmetric Aza??Claisen Rearrangement: Development of Widely Applicable Pentaphenylferrocenyl Palladacycle Catalysts

DF Fischer, A Barakat, Z Xin, ME Weiss…

Index: Fischer, Daniel F.; Barakat, Assem; Xin, Zhuo-Qun; Weiss, Matthias E.; Peters, Rene Chemistry - A European Journal, 2009 , vol. 15, # 35 p. 8722 - 8741

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Citation Number: 74

Abstract

Abstract Systematic studies have been performed to develop highly efficient catalysts for the asymmetric aza-Claisen rearrangement of trihaloacetimidates. Herein, we describe the stepwise development of these catalyst systems involving four different catalyst generations finally resulting in the development of a planar chiral pentaphenylferrocenyl oxazoline palladacycle. This complex is more reactive and has a broader substrate tolerance than ...