Abstract: Saponification of the heptaacetate of daunomycin hydroquinone (6) with 7 equiv of lithium hydroxide to N-acetyldaunomycin hydroquinone (7) in argon-degassed tetrahydrofuran (THF)/water medium was reported earlier not to give rise to glycosidic cleavage to yield 7-deoxydaunomycinone (5)(J. Am. Chem. SOC. 1991, 113, 1373). The only product characterized after exposure to air was N-acetyldaunomycin (8). The result ...
[Sulikowski, Gary A.; Turos, Edward; Danishefsky, Samuel J.; Shulte, Gayle M. Journal of the American Chemical Society, 1991 , vol. 113, # 4 p. 1373 - 1377]
[Sulikowski, Gary A.; Turos, Edward; Danishefsky, Samuel J.; Shulte, Gayle M. Journal of the American Chemical Society, 1991 , vol. 113, # 4 p. 1373 - 1377]
![N-[6-[(3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl)oxy]-3-hydroxy-2-methyloxan-4-yl]acetamide Structure](https://image.chemsrc.com/caspic/437/32385-10-7.png)
