The structure of the sulfur-containing moiety of vitamin BI was elucidated by Clarke and Gurin. 1 The correctness of their proof has been established by the syntheses of the vitamin, reported by Cline, Williams and Finkelstein2 and by Todd and Bergel. 3 In connection with experiments along similar lines that are being carried out in this Laboratory, a study of 4- methylthiazole-5-acetic acid and some of its derivatives suggested itself. We chose this ...
