Pd??Catalyzed Synthesis of Biphenyls with Methylthio Group

Z Zhang, Z Hu, Z Yu, H Chi, P Lei, Y Wang…

Index: Zhang, Zhiqiang; Hu, Zhizhi; Yu, Zhixiao; Chi, Haijun; Lei, Peng; Wang, Yue; He, Ren Synthetic Communications, 2007 , vol. 37, # 5 p. 683 - 690

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Abstract

Abstract The synthesis of unsymmetrical biaryls with a methylthio group is achieved using the air??stable palladium–phosphinous acid complexes,[(t??Bu) 2P (OH)] 2 PdCl2 (POPd), as the catalyst. A great variety of substituted bromobenzenes having electron??withdrawing and electron??donating functional groups in para and meta positions have been successfully coupled with 3??methylthiophenylboronic acid.