Thelepamide: An Unprecedented Ketide-Amino Acid from Thelepus crispus, a Marine Annelid Worm

…, M Blanco, FA Valeriote, C Jimenez, P Crews

Index: Rodriguez, Jaime; Nieto, Rosa M.; Blanco, Maria; Valeriote, Frederick A.; Jimenez, Carlos; Crews, Phillip Organic Letters, 2014 , vol. 16, # 2 p. 464 - 467

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Citation Number: 12

Abstract

Thelepamide (1) was characterized during a program to study cytotoxic substances from an unusual source, the tidal zone-derived annelid Thelephus crispus. Its structure contains a tetraketide and a tripeptide subunit and possesses striking atom diversity, consisting of 17 carbons and 8 heteroatoms. The relative configurations at four chiral sites were elucidated via ROESY, J-based configurational analysis, and DFT calculations. It was modestly active ...