Tetrahedron letters

Synthesis of two possible diastereomers of reticulatain-1

…, A Miyawaki, R Takahashi, Y Hattori, H Konno, M Abe…

Index: Makabe, Hidefumi; Miyawaki, Aya; Takahashi, Ryoko; Hattori, Yasunao; Konno, Hiroyuki; Abe, Masato; Miyoshi, Hideto Tetrahedron Letters, 2004 , vol. 45, # 5 p. 973 - 977

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Citation Number: 34

Abstract

A convergent synthesis of two possible diastereomers of reticulatain-1 (and) was accomplished. Comparison of the specific optical rotations of and did not allow for the strict determination of the absolute configuration. However, bis-(R)-MTPA esters of and showed a clear difference in chemical shifts in the 1H NMR spectra. If the bis-(R)-MTPA ester of natural reticulatain-1 () is available, the absolute configuration of will be determined. Inhibitory ...