Organic letters

Direct oxidative conversion of methylarenes into aromatic nitriles

D Tsuchiya, Y Kawagoe, K Moriyama, H Togo

Index: Tsuchiya, Daisuke; Kawagoe, Yuhsuke; Moriyama, Katsuhiko; Togo, Hideo Organic Letters, 2013 , vol. 15, # 16 p. 4194 - 4197

Full Text: HTML

Citation Number: 22

Abstract

A variety of methylarenes were successfully converted into the corresponding aromatic nitriles in good to moderate yields by the treatment with NBS or DBDMH in the presence of a catalytic amount of AIBN or BPO, followed by the reaction with molecular iodine in aq NH3 in a one-pot procedure. The present reaction is a useful and practical transition-metal-free method for the preparation of aromatic nitriles from methylarenes.