Benzocycloalkyl and benzocycloalkenyl moities linked, directly or via an alkyl chain, to oxygenbearing heteroarylpiperazines were synthesized, in an attempt to obtain potent and selective antagonists at postsynaptic 5-HT1. 4 receptors. From the numerous arylpiperazines described in the literature, 1-(2, 3-dihydro-1, 4-benzodioxin-5-yl) piperazine (3a) was chosen as a model of an arylpiperazine in view of its selectivity for 5-HT1. 4 ...
