Tetrahedron

Synthesis of highly substituted tetrahydropyrans: preparation of the C20–C28 moiety of phorboxazoles

TK Chakraborty, VR Reddy, TJ Reddy

Index: Chakraborty, Tushar K.; Reddy, V. Ramakrishna; Reddy, T. Jagadeshwar Tetrahedron, 2003 , vol. 59, # 43 p. 8613 - 8622

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Citation Number: 19

Abstract

A propionate-derived polyketide building block A whose 2-methyl-1, 3-diol moiety was built by a Ti (III)-mediated ring opening reaction of a trisubstituted 2, 3-epoxy alcohol precursor was employed as a common starting material for the syntheses of highly substituted tetrahydropyrans 1–5, the first one being the C20–C28 fragment of cytotoxic natural products, phorboxazoles.