Total synthesis of quinocarcinol methyl ester

…, PJ Harrison, RR Webb, BT O'Neill

Index: Danishefsky, Samuel J.; Harrison, Peter J.; Webb II, Robert R.; O'Neill, Brian T. Journal of the American Chemical Society, 1985 , vol. 107, # 5 p. 1421 - 1423

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Citation Number: 45

Abstract

yield (overall from 7) of Boc acetate as a single crystalline compound, mp 106-108" C. Conversion of the allyl group to a 3.5: l mixture of E/Z isomers 11 was accomplished in quantitative (crude) yield through the agency of PdCl,.(MeCN) 2 in methanol. IO The tetrahydroisoquinoline ring system was established1Ia by the reaction of 11 with the Nicolaou reagent, N-phenylselenophthalimide, Ilb in the presence of camphorsulfonic ...