In view of the key role of the PARP-1 in maintaining the genomic integrity, particularly in the repair of single-strand DNA lesions which caused by ionizing radiation, chemotherapy, or products of cellular and oxidative metabolism, PARP-1 has emerged as an attractive anticancer drug target. 4 Another major breakthrough highlights that PARP-1 inhibitors can be used as single-agent therapy to kill tumors with mutation in BRCA1- and BRCA2-dependent DNA ...
