DMAP-catalyzed synthesis of 2-oxazolidinones from corresponding halohydrins using KOCN/DMF

…, GR Babu, L Gangaiah, K Mukkanti, G Madhusudhan

Index: Chinnam Naidu; Ravi Babu; Gangaiah; Mukkanti; Madhusudhan Tetrahedron Letters, 2010 , vol. 51, # 8 p. 1226 - 1229

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Citation Number: 10

Abstract

We report facile and simple synthesis of a variety of 2-oxazolidinones from the corresponding halohydrins by reaction with KOCN in DMF catalyzed by DMAP. DMAP and temperature play key roles in enriching the yield of 2-oxazolidinones. A few examples in this Letter are applicable to pharmaceutically important processes.