Tetrahedron

Suzuki–Miyaura reactions of N-protected tribromopyrazoles. Efficient and site-selective synthesis of 3, 4, 5-triaryl-pyrazoles, 3, 5-diaryl-4-bromopyrazoles and 5-aryl-3, …

…, M Hussain, J Tatar, A Saeed, A Villinger, P Langer

Index: Khera, Rasheed Ahmad; Ali, Asad; Rafique, Hummera; Hussain, Munawar; Tatar, Jovana; Saeed, Aamer; Villinger, Alexander; Langer, Peter Tetrahedron, 2011 , vol. 67, # 29 p. 5244 - 5253

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Citation Number: 13

Abstract

Abstract Suzuki–Miyaura reactions of N-protected tribromopyrazoles were studied. The reactions proceed with excellent site-selectivity. The first attack occurs at position 5, while the second and third attack occur at positions 3 and 4, respectively. A variety of 3, 4, 5-triaryl- pyrazoles, 3, 5-diaryl-4-bromopyrazoles, and 5-aryl-3, 4-dibromopyrazoles were efficiently prepared. The products are not readily available by other methods.