In continuation of our ongoing programme of synthesizing polyketide natural products by applying a desymmetrization strategy, we embarked on the total synthesis of crocacins. Herein, we describe the stereoconvergent synthesis of an advanced intermediate, a linear trienoate, for the synthesis of crocacin C utilizing asymmetric hydroboration, cross-metathesis and modified Julia olefination reactions. ... Acid catalyzed methanolysis of the bicyclic lactone 8 proceeded smoothly to ...
![(E)-ethyl 4-(benzo[d]thiazol-2-ylthio)-3-methylbut-2-enoate Structure](https://image.chemsrc.com/caspic/488/106484-52-0.png)
