Synthesis of the C31–C67 Fragment of Amphidinol 3

…, JR Huckins, SD Rychnovsky

Index: De Vicente, Javier; Huckins, John R.; Rychnovsky, Scott D. Angewandte Chemie - International Edition, 2006 , vol. 45, # 43 p. 7258 - 7262

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Citation Number: 30

Abstract

The amphidinols are a structurally unique group of metabolites isolated from the marine dinoflagellates Amphidinium klebsii and Amphidinium carterae.[1] Amphidinol 3 (AM3; 1) is one of the most biologically active compounds in this class, as it exhibits potent hemolytic activity against human erythrocytes and antifungal activity against Aspergillus niger.[1] Key structural features of AM3 include two highly substituted tetrahydropyran (THP) rings, a ...

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