Tetrahedron letters

Convenient one-step synthesis of a medicinally relevant benzopyranopyridine system

…, AA Yakovenko, MY Antipin, IV Magedov, A Kornienko

Index: Evdokimov, Nikolai M.; Kireev, Artem S.; Yakovenko, Andrey A.; Antipin, Mikhail Yu.; Magedov, Igor V.; Kornienko, Alexander Tetrahedron Letters, 2006 , vol. 47, # 52 p. 9309 - 9312

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Citation Number: 35

Abstract

Benzopyrano [2, 3-b] pyridine is an important privileged medicinal scaffold. A three- component reaction of salicylaldehydes, thiols and 2equiv of malononitrile that leads to the formation of a series of compounds incorporating 2, 4-diamino-3-cyano-5- sulfanylbenzopyrano [2, 3-b] pyridine framework is described. A proposed mechanism with the supporting experimental data is presented.