Tetrahedron Letters

Staudinger and retro-Staudinger reactions. The dichloro-β-lactam moiety as a useful handle for the synthesis of 4-aryl-2H-1, 3-benzothiazine 1, 1-dioxides

L Fodor, P Csomós, A Csámpai, P Sohár

Index: Fodor, Lajos; Csomos, Peter; Csampai, Antal; Sohar, Pal Tetrahedron Letters, 2010 , vol. 51, # 24 p. 3205 - 3207

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Citation Number: 10

Abstract

The dichloro-β-lactam ring, obtained via Staudinger reaction of 4-aryl-2H-1, 3- benzothiazines, proved to be a useful protecting strategy for the synthesis of 4-aryl-2H-1, 3- benzothiazine 1, 1-dioxides. After oxidation of the 1, 1-dichloroazeto [2, 1-c][1, 3]- benzothiazin-2-ones, the thiazine ring could be recovered selectively and in good yield by treatment with base. Thus, novel 4-aryl-2H-1, 3-benzothiazine 1, 1-dioxides were obtained ...