Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: Synthesis, structure–activity relationships, and pharmacokinetics

…, D Yan, RF Arrendale, GP Reddy, T Evers…

Index: Ndungu, J. Maina; Krumm, Stefanie A.; Yan, Dan; Arrendale, Richard F.; Reddy, G. Prabhakar; Evers, Taylor; Howard, Randy; Natchus, Michael G.; Saindane, Manohar T.; Liotta, Dennis C.; Plemper, Richard K.; Snyder, James P.; Sun, Aiming Journal of Medicinal Chemistry, 2012 , vol. 55, # 9 p. 4220 - 4230

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Citation Number: 15

Abstract

The measles virus (MeV), a member of the paramyxovirus family, is an important cause of pediatric morbidity and mortality worldwide. In an effort to provide therapeutic treatments for improved measles management, we previously identified a small, non-nucleoside organic inhibitor of the viral RNA-dependent RNA polymerase by means of high-throughput screening. Subsequent structure–activity relationship (SAR) studies around the ...