Synthesis and structure–activity studies of novel homomorpholine oxazolidinone antibacterial agents

…, FE Boyer, AL Choy, MD Huband, PJ Pagano…

Index: Kim, Ji-Young; Boyer, Frederick E.; Choy, Allison L.; Huband, Michael D.; Pagano, Paul J.; Vara Prasad Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 550 - 553

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Citation Number: 19

Abstract

A novel series of oxazolidinones were synthesized in which the morpholine C-ring of linezolid was replaced with homomorpholine. In addition to investigating the effect of a homomorpholine C-ring on antibacterial activity, the effect of des-, mono-, di-, and tri-fluoro substitution on the phenyl B-ring was investigated as well. Various C-5 functional groups were also examined, including acetamides and triazoles and carboxamides.