Design, synthesis, and antitumor evaluation of novel acenaphtho [1, 2-b] pyrrole-carboxylic acid esters with amino chain substitution

F Liu, X Qian, J Cui, Y Xiao, R Zhang, G Li

Index: Liu, Fengyu; Qian, Xuhong; Cui, Jingnan; Xiao, Yi; Zhang, Rong; Li, Gangyue Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 13 p. 4639 - 4644

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Citation Number: 13

Abstract

8-Oxo-8H-acenaphtho [1, 2-b] pyrrole-9-carboxylic acid esters and derivatives were prepared and evaluated for cytotoxicity against A549 and P388 cell lines. Based on a novel chromophore precursor 8-oxo-8H-acenaphtho [1, 2-b] pyrrol-9-carbonitrile 1, the very insoluble 1 was converted to more soluble esters 5 and a series of 3-amino derivatives from 5 were obtained by mild SNArH reaction between 5 and various amines. The biological ...