Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues

…, JP Jukes, H Ghadbane, LR Cox, V Cerundolo…

Index: Jervis, Peter J.; Moulis, Marie; Jukes, John-Paul; Ghadbane, Hemza; Cox, Liam R.; Cerundolo, Vincenzo; Besra, Gurdyal S. Carbohydrate Research, 2012 , vol. 356, p. 152 - 162

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Citation Number: 13

Abstract

A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6 ″-azido-6 ″-deoxy-α- galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells.