Potent Inhibitors of tRNA??Guanine Transglycosylase, an Enzyme Linked to the Pathogenicity of the Shigella Bacterium: Charge??Assisted Hydrogen Bonding

…, C Kramer, WB Schweizer, B Wagner…

Index: Hoertner, Simone R.; Ritschel, Tina; Stengl, Bernhard; Kramer, Christian; Schweizer, W. Bernd; Wagner, Bjoern; Kansy, Manfred; Klebe, Gerhard; Diederich, Francois Angewandte Chemie - International Edition, 2007 , vol. 46, # 43 p. 8266 - 8269

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Citation Number: 24

Abstract

Dedicated to Professor Dieter Seebach on the occasion of his 70th birthday tRNA-Guanine transglycosylase (TGT, EC 2.4. 2.29) is a tRNA-modifying enzyme common to nearly all organisms including humans.[1] In bacteria, TGT catalyzes the exchange of guanine in position 34 by preQ1, whereas eukaryotic TGT accelerates the replacement by queuine.[2] This difference in substrate specificity offers the possibility for selective inhibition of the ...