Surface-enhanced Raman spectroscopy (SERS) has recently emerged as an alternative to fluorescence-based spectroscopy in bioimaging, as it can minimize photobleaching, peak overlapping, and low signal-to-noise ratio in complex biological systems.[1–3] SERS probes are based on the 1014–1016-fold scattering enhancement caused by the proximity of Ramanactive signature molecules to the surface of metal nanoparticles (NPs),[4–7] which ...
