Synthesis

Synthesis of ω-aminodithioesters

S Lacroix, V Rixhon, J Marchand-Brynaert

Index: Lacroix, Simon; Rixhon, Vinciane; Marchand-Brynaert, Jacqueline Synthesis, 2006 , # 14 p. 2327 - 2334

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Citation Number: 12

Abstract

Abstract ω-Aminodithioester derivatives were obtained from thionolactams by reaction with an alkyl triflate followed by thiolysis with hydrogen sulfide. The presence of an electron- withdrawing group was required on the N1 position (p-nitrophenyl or benzoyl) to favor the ring opening of γ-, δ-and ε-thionolactams. In the case of β-thionolactam, activation was provided by a CF 2 motif in C3 position