Microsomal activation of dibenzo [def, mno] chrysene (anthanthrene), a hexacyclic aromatic hydrocarbon without a bay-region, to mutagenic metabolites

KL Platt, C Degenhardt, S Grupe, H Frank…

Index: Platt, Karl L.; Degenhardt, Christian; Grupe, Stefanie; Frank, Heinz; Seidel, Albrecht Chemical Research in Toxicology, 2002 , vol. 15, # 3 p. 332 - 342

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Citation Number: 8

Abstract

Metabolically formed dihydrodiol epoxides in the bay-region of polycyclic aromatic hydrocarbons are thought to be responsible for the genotoxic properties of these environmental pollutants. The hexacyclic aromatic hydrocarbon dibenzo [def, mno] chrysene (anthanthrene), although lacking this structural feature, was found to exhibit considerable bacterial mutagenicity in histidine-dependent strains TA97, TA98, TA100, and TA104 of S. ...