Core modification of cytisine: A modular synthesis

C Hirschhäuser, CA Haseler…

Index: Hirschhaeuser, Christoph; Haseler, Claire A.; Gallagher, Timothy Angewandte Chemie - International Edition, 2011 , vol. 50, # 22 p. 5162 - 5165

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Citation Number: 20

Abstract

(À)-Cytisine (1) has occupied a pivotal role in nicotinic pharmacology as a partial agonist at the α4β2 subtype of neuronal nicotinic acetylcholine receptor (nAChR).[1] More recently because of this partial agonist profile, cytisine provided the discovery lead for varenicline (2), Pfizer s smoking cessation agent which was launched in 2006.[2, 3] Recent interest in the chemistry of cytisine (1) has been high because of a lack of understanding as to the ...