Phase separation as a strategy toward controlling dilution effects in macrocyclic Glaser-Hay couplings

AC Bédard, SK Collins

Index: Bedard, Anne-Catherine; Collins, Shawn K. Journal of the American Chemical Society, 2011 , vol. 133, # 49 p. 19976 - 19981

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Citation Number: 39

Abstract

Macrocycles are abundant in numerous chemical applications, however the traditional strategy for the preparation of these compounds remains cumbersome and environmentally damaging; involving tedious reaction set-ups and extremely dilute reaction media. The development of a macrocyclization strategy conducted at high concentrations is described which exploits phase separation of the catalyst and substrate, as a strategy to control ...